癌癥

Zon 課題組用斑馬魚胚胎進行藥物篩選, 發(fā)現(xiàn)了雙氫乳清酸酯脫氫酶 (Dihydroorotate dehydrogenase, DHODH)的抑制劑, 比如來氟米特(Leflunomide), 能抑制神經(jīng)脊細胞發(fā)育。在哺乳動物模型里的實驗表明, 通過抑制DHODH 可以有效抑制黑素瘤在體外和體內(nèi)的增殖。Leflunomide 也被批準進入了臨床實驗, 與Vemurafenib 聯(lián)合用藥治療黑素瘤(ClinicalTrials.gov Identifier NCT01611675)。

（Patton, E.E., Widlund, H.R., Kutok, J.L., Kopani, K.R., Amatruda, J.F., Murphey, R.D., Berghmans, S., Mayhall, E.A., Traver, D., Fletcher, C.D., et al. (2005). BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Current biology : CB 15, 249-254